Voja Antonic over at Hackaday posted a detailed how-to on building enclosure out of FR4— AKA PCBS:
Another way is to build the enclosure out of FR4, a material which is commonly used in PCB production. Such enclosures are low-cost, with thin walls but yet very strong, nice looking, pleasant to the touch and have excellent thermal and moisture stability. FR4 offers some more possibilities – efficient wiring with no wires inside the housing, integrated UHF or SHF antennas or RFID coils, capacitive switches, electrical shielding, selective semi-transparency, water or air tightness, and even integration of complex mechanical assemblies.
Here I shall explain the process of building those “magic” enclosures. It is based on nearly fifty years of personal experience and more than a hundred enclosures, built for most of my projects. Here are two examples – this case for a hardware password manager is just a few centimeters long, while the other one (protective transportation cover for my son’s synthesizer) measures 125cm (about 49 inches), and yet both of them are strong enough to withstand a grown man standing on top of them.