Nixie tubes are started with a high initial voltage Vigh, around 150-180volts. Once ignited they work at a maintaining voltage Vm, and consume a average current Ik. To drive them you need a current limiting resistor and a high voltage power source that is equal to their Vigh.
The resistor is calculated by the formula R = (Vign -Vm) / Ik, and the power dissipated by the resistor is calculated by P = (Vign – Vm) * Ik.
Once a resistor is selected the rest of the circuit surmises down to controlling the ground of the tube with a NPN transistor, or a open collector output IC. You can check out his circuit in action in the video below.