Simplify USB to I2C connectivity by using this app note from FTDI.
The FT2232H and FT4232H are the FTDI’s first USB 2.0 Hi-Speed (480Mbits/s) USB to UART/FIFO ICs. They also have the capability of being configured in a variety of serial interfaces using the internal MPSSE (Multi-Protocol Synchronous Serial Engine).
This application note illustrates how to use the MPSSE of the FT2232H to interface with the I2C bus. Users can use the example schematic and functional software code to begin their design. Note that software code is provided as an illustration only and not supported by FTDI.