Hey,
Can I suggest a BusPirate mode that, when activated, makes ttyUSB0 into a generic SPI/I2C/UART-to-USB converter until it is removed from power?
IE, connect, set mode, options, etc, then set the 'automagic mode', then disconnect.
Then be able to, IE, stream data off of /dev/ttyUSB0 into a GPS program, etc.
It'd make for easier testing of UART things in environments that are already known (IE, dumping NMEA data into a GPS program)