I wanted to test out my new setup so I tried to create a home made bus pirate pcb, all in all the results were pretty good, the board came out real well and drilling didn't give me any problems, the small vias tend to be a bit weak so spraying over a protective coating is pretty important.
To do the through hole plating I use small wires if I can afford a bump on the board where I soldered it or fill it with a conductive paint, if using conductive paint you can simply put some sticky tape over the board before drilling to prevent the paint from going anywhere unintended.
I've made some pretty stupid mistakes in the past with my layouts so I prefer making a cheap prototype first, what do you guys prefer, going cheap or doing a professional prototype run?
[EDIT]
Oh, I did a single layer board because I overexposed the first attempt which was double layer, the results are near perfect with double layer since alignment when using photo resist is pretty good.